Xiaflex

Treatment for adults with Dupuytren's contracture when a "cord" can be felt.
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Take a step toward treating your Dupuytren's contracture by exploring a potential treatment option today. Learn more about XIAFLEX, the first and only FDA-approved nonsurgical treatment option with proven efficacy in clinical studies for adults with Dupuytren's contracture when a "cord" can be felt.

In two clinical studies, 44% and 64% of patients receiving XIAFLEX (versus 5% and 7% of patients receiving placebo) had a straight or nearly straight finger after up to 3 XIAFLEX injection procedures. Most people required 1 or 2 injection procedures of XIAFLEX to help "break" the cord.

How XIAFLEX is Administered

For adults with Dupuytren’s contracture when a "cord" can be felt, XIAFLEX provides a treatment option that requires no incisions to administer and no physical therapy post treatment beyond finger exercises you can do at home. First, you receive the XIAFLEX injection. The next day, the doctor may need to straighten the affected finger. Thirty days later, the doctor will check your progress in a follow-up visit.

XIAFLEX should be administered by a healthcare provider experienced in injection procedures of the hand and in the treatment of Dupuytren’s contracture. XIAFLEX can cause serious side effects including tendon rupture. See additional Important Safety Information.

Preparing for Your Appointment

We’ve put together some tools to help you prepare for your next appointment with your doctor, so the two of you can decide together what treatment option may be right for you.

Find a Doctor

Wondering if XIAFLEX is right for you? The first step is to talk to a doctor, who will determine what treatment option may be right for you by taking into consideration your diagnosis and any medications you may be taking. Use our search tool to find doctors in your area who are experienced with XIAFLEX.

What is XIAFLEX?

XIAFLEX is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18.

IMPORTANT SAFETY INFORMATION

Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, or increased pain in your treated finger or hand after your injection or after your follow-up visit
  • Allergic reactions. Severe allergic reactions can happen in people who receive XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.

Please see the accompanying full Prescribing Information and Medication Guide.